This interaction is presumed to be responsible for lorazepam's mechanism of action. Lorazepam exhibits relatively high and specific affinity for its recognition site.
Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. Monitor patients for respiratory depression and sedation (see WARNINGS and PRECAUTIONS, Drug Interactions ).
Because of its prolonged duration of action, the prescriber should be alert to the possibility, especially when multiple doses have been given, that the sedative effects of lorazepam may add to the impairment of consciousness seen in the post-ictal state.
WARNING: RISKS FROM CONCOMITANT USE WITH OPIOIDS.
PRIOR TO INTRAVENOUS USE, Ativan INJECTION MUST BE DILUTED WITH AN EQUAL AMOUNT OF COMPATIBLE DILUENT (see DOSAGE AND ADMINISTRATION ).
This review details the present knowledge about BZD mechanisms of action, drug. Lorazepam binds GABA-A with less affinity than alprazolam but with greater.
Benzodiazepines (BZDs) are one of the most widely prescribed pharmacologic agents in the United States (more than 112 million prescriptions in 2007). However, these properties become undesired side effects in nearly all other clinical instances. 1 BZDs are used for numerous indications, including anxiety, insomnia, muscle relaxation, relief from spasticity caused by central nervous system pathology, and epilepsy. BZDs are also used intraoperatively because of their amnesic and anxiolytic properties.
For any patient taking a BZD, the prescribing physician must carefully evaluate the risks and benefits, and higher-risk patients require careful considerations.
Lorazepam (Ativan) is another benzodiazepine available for parenteral administration. Its action following parenteral administration is primarily that of sedation.
From: Pediatric Critical Care (Fourth Edition), 2011.
0.18 ml polyethylene glycol 400 in propylene glycol.
The use of lorazepam the evening before treatment to ensure a restful night's sleep appears more reasonable. Because of the greater possibility of unwanted sedation with lorazepam than with other benzodiazepines, its use in the immediate preoperative period should be discouraged unless the dentist desires this effect and if arrangements have been made for the patient to be escorted from the office by a responsible adult companion.
Pregnancy category D Lactation NS Metabolism Liver Excretion Urine, half-life 14 hr DEA schedule IV Read full chapter.
The metabolisms of different BZDs are intertwined with each other.
Anxiolytic and sedative actions: Lorazepam depresses the CNS at the limbic and subcortical levels of the brain. It produces an antianxiety effect by influencing.
Then dosage is divided, p.r.n. over 5 minutes 45 minutes before chemotherapy. h.s. Or, 1.5 mg/m2 (maximum 3 mg) I.V. Usual range is 2 to 6 mg P.O. Elderly patients: Initially, 1 to 2 mg P.O. Status epilepticus ◇. Adults: 0.05 mg/kg I.M. Adults: 2 to 4 mg P.O. Preoperatively. daily in divided doses; maximum dose is 10 mg daily. 2 hours before surgery (maximum, 4 mg). Adults: 2.5 mg P.O. Doses may be repeated at 10- to 15-minute intervals as needed for seizure control. Adults: Initially, 2 to 3 mg P.O.
Benzodiazepines have GABA-potentiating actions in the CNS (spinal cord, hippocampus, cerebellum, cerebrum) thereby reducing neuronal.
This information is drawn from a number of sources (see below). The reader is encouraged to access these and other relevant literature for more detail. As always, sound clinical judgment should be used in individual clinical cases. In particular, it should be remembered that there may be significant variation in the pharmokinetics of a drug resulting from a number of factors, including the individual patient’s metabolism/disease status and how the medication has been formulated.
Benzodiazepines have GABA-potentiating actions in the CNS (spinal cord, hippocampus, cerebellum, cerebrum) thereby reducing neuronal activity.
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Onset of action: 5 minutes SL; 10-15 minutes PO Time to peak: 1-1.5 h SL/SC, 1-6 h PO Duration of action: 6-72 h Plasma ½ life: 12-15 h.