Anyone considering the use of Nardil or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term.
The most important reaction associated with NARDIL administration is the occurrence of hypertensive crises, which have sometimes been fatal.
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Patients with major depressive disorder (MDD), both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation and behavior (suicidality) or unusual changes in behavior, whether or not they are taking antidepressant medications, and this risk may persist until significant remission occurs.
NARDIL (phenelzine sulfate) is a potent inhibitor of monoamine oxidase (MAO).
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Although a causal link between the emergence of such symptoms and either the worsening of depression and/or the emergence of suicidal impulses has not been established, there is concern that such symptoms may represent precursors to emerging suicidality. The following symptoms, anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia (psychomotor restlessness), hypomania, and mania, have been reported in adult and pediatric patients being treated with antidepressants for major depressive disorder as well as for other indications, both psychiatric and nonpsychiatric.
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Safety and effectiveness in the pediatric population have not been established (see BOX WARNING and WARNINGS — Clinical Worsening And Suicide Risk ).
Table 1 Age Range Drug-Placebo Difference in Number of Cases of Suicidality per 1000 Patients Treated Increases Compared to Placebo <18 14 additional cases 18–24 5 additional cases Decreases Compared to Placebo 25–64 1 fewer case ≥65 6 fewer cases.
This syndrome generally responds to reinstitution of low-dose NARDIL therapy followed by cautious downward titration and discontinuation.
Find patient medical information for Nardil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
l your doctor right away if any of these unlikely but serious side effects occur: fainting, mental/mood changes (e.g., agitation, confusion), muscle stiffness, changes in sexual ability/interest, shaking (tremor), shivering, swollen ankles /legs, unusual weight gain, eye pain /swelling/redness, vision changes (e.g., double/blurred vision ).
If you have heart disease, this medication may mask chest pain. Avoid strenuous exercise while taking this medication.
It is very important that you follow special dietary restrictions in order to limit the amount of tyramine in your diet.
Nardil should not be used in patients who are hypersensitive to any of the ingredients or with phaeochromocytoma, cerebrovascular disease.
The capacity of MAOIs to act as antidepressants has most often been assumed to reflect the increased availability of one or more monoamines in the CNS or sympathetic nervous system.
Nardil is a registered trade mark.
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Easy to read patient leaflet for Nardil. Includes indications, proper use, special instructions, precautions, and possible side effects.
Symptoms may include confusion; dizziness; drowsiness; excitement; fast heartbeat; flushing; irritability; restlessness; seizures; sweating; weakness. Contact (the American Association of Poison Control Centers), your local poison control center, or emergency room immediay.
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:.
l your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:.