To reduce the development of drug-resistant bacteria and maintain the effectiveness of Macrobid and other antibacterial drugs, Macrobid should be used only to.
Plasma nitrofurantoin concentrations after a single oral dose of the 100 mg Macrobid capsule are low, with peak levels usually less than 1 mcg/mL. Nitrofurantoin is highly soluble in urine, to which it may impart a brown color. When Macrobid is administered with food, the bioavailability of nitrofurantoin is increased by approximay 40%
Nitrofurantoin has been shown in one published transplacental carcinogenicity study to induce lung papillary adenomas in the F1 generation mice at doses 19 times the human dose on a mg/kg basis.
Macrobid (nitrofurantoin monohydrate/macrocrystals) Capsules. To reduce the development of drug-resistant bacteria and maintain the.
Distributed by: Almatica Pharma, Inc. Pine Brook, NJ 07058 USA. Rev: 02/2013.
The following additional clinical adverse events have been reported with the use of nitrofurantoin:
Uricosuric drugs, such as probenecid and sulfinpyrazone, can inhibit renal tubular secretion of nitrofurantoin. The resulting increase in nitrofurantoin serum levels may increase toxicity, and the decreased urinary levels could lessen its efficacy as a urinary tract antibacterial.
Meets USP Dissolution Test 2 REFERENCES.
Changes in EKG (e.g., non-specific ST/T wave changes, bundle branch block) have been reported in association with pulmonary reactions.
Anuria, oliguria, or significant impairment of renal function (creatinine clearance under 60 mL per minute or clinically significant elevated serum creatinine) are contraindications (see CONTRAINDICATIONS ).
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Properly discard this product when it is expired or no longer needed. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. 2016 First Databank, Inc. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.Information last revised July 2016.
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Macrobid (nitrofurantoin) is an antibiotic used to treat urinary tract infections. Includes side effects, interactions and indications.
Usual Pediatric Dose for Cystitis:
liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or.
new or worsening cough, trouble breathing;
if you are urinating less than usual or not at all; or.
Use only the type of antacid your doctor recommends. Avoid using antacids without your doctor's advice. Some antacids can make it harder for your body to absorb nitrofurantoin.
Do not take Macrobid if you are in the last 2 to 4 weeks of pregnancy.
Do not take extra medicine to make up the missed dose.
MacroBid: Nitrofurantoin belongs to the class of medications called antibiotics. It is used to treat urinary tract infections or bladder infections caused by certain.
Nitrofurantoin should be taken with food or milk to reduce the risk of stomach upset. The recommended dose of this medication for adults and children over 12 years old is 100 mg twice daily.
If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor. The side effects listed below are not experienced by everyone who takes this medication.
Ask your pharmacist how to dispose of medications that are no longer needed or have expired. Do not dispose of medications in wastewater (e.g.